Investigation on external stimuli engendered magnetic ordering in polycrystalline CaCu3Ti4O12 quadruple perovskite

The consequences of high energy mechanical milling, microwave-assisted heating and rapid thermal cooling on magnetic ordering in polycrystalline CaCu₃Ti₄O₁₂ cubic perovskite have been investigated by means of X-ray powder diffractometry (300?K), dc magnetization in field – cooled and zero – field cooled modes (H = 100?Oe and 1000?Oe, T?=?5–300?K) (M – T curves) and M – H loop characteristics (T?=?5?K and 300?K, H_max = 70?kOe). The M – T curves of unmilled and 16?h milled samples show pure antiferromagnetic and weak ferromagnetic ordering, respectively, 1?h and 6?h milled samples demonstrate the coexistence of both the phases while microwave-assisted and quenched samples exhibit classic antiferromagnetic transition and a low temperature paramagnetic–like contribution with different weights, well supported by the M – H loop characteristics. The observed transformations in the magnetic ordering are attributed to the ball-milling induced stress which curtails hybridization of empty Ti-3d orbitals with Cu-3d and O-2p orbitals and secondary phase formation. Oxygen vacancies associated with bound magnetic polarons originate ferromagnetism in the milled samples while unpaired electrons inhabited at the empty sites are the cause of paramagnetic centers. The low-temperature Curie – tail in M – T curve for quenched and microwave assisted samples is attributed to Ti³⁺ cations.     

Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide

We used N-methylpyrrole (Py)-N-methylimidazole-(Im) polyamide as an exogenous agent to modulate the formation of DNA assemblies at specific double-stranded sequences. The concept was demonstrated on the hybridization chain reaction that forms linear DNA. Through a series of melting curve analyses, we demonstrated that the binding of Py−Im polyamide positively influenced both the HCR initiation and elongation steps. In particular, Py−Im polyamide was found to drastically stabilize the DNA duplex such that its thermal stability approached that of an equivalent hairpin structure. Also, the polyamide served as an anchor between hairpin pairs in the HCR assembly, thus improving the originally weak interstrand stability. We hope that these proof-of-concept results can inspire future use of Py−Im polyamide as a molecular tool to modulate the formation of DNA assemblies.     

Transporters in the neurohypophysial neuroendocrine system, with special reference to vesicular glutamate transporters (BNPI and DNPI): a review.

Recent advances in gene technology have helped to identify novel proteins and allowed study of their distribution and functions in the mammalian brain. One class of these proteins is that of transporters, which exist in plasma and organellar membranes of neurons and other cells to move substances selectively across membranes. These transporters can be categorized further into subclasses by their structural property, substrate selectivity, and site of action. Some of them have been identified in the hypothalamus, which is the only brain site where a neural signal is converted to a humoral one, namely, a hormone for a target organ. This unique neural mechanism has long attracted attention as the neuroendocrine system, part of which has been extensively studied as the hypothalamic-neurohypophysial system involved in secretion of vasopressin and oxytocin. However, transporters in this system have been less well studied. A morphological examination of novel transporters would give us cues to a better understanding of the neuronal organization and function of the system. In this review, we first summarize recent findings on expression of transporter gene and immunoreactivity in the hypothalamus. In the second part, we explain our observations on two vesicular glutamate (inorganic phosphate) transporters (BNPI and DNPI) in the supraoptic and paraventricular nuclei and neurohypophysis. Further study of these and other transporters will provide a basis on which to reevaluate the organization and function of the hypothalamic-neurohypophysial system.     

靶向抗癌药格列卫与其治疗白血病疗效监测

Gleevec是抑制致癌的融合蛋白BCR-ABL的一种分子靶向治疗药物,BCR-ABL是一种与慢性髓细胞性白血病(CML)有关的酪氨酸激酶抑制剂。用Gleevec选择性地抑制BCR-ABL活性在治疗CML中显示出很好的效果,特别是在CML慢性期,因此,监测疗效非常重要。现就Gleevec的研究进展及如何监测其在CML中的疗效作一简单综述。     

He－Ne激光对小麦属间杂交影响的研究

１９８８～１９９２年，作者采用Ｈｅ－Ｎｅ激光辐照黑麦花粉与杂交相结合的方法，对小麦属间杂交（普通小麦×黑麦）进行了研究。属间杂交所获种子的结实率极显著高于对照，为１１３．２５～３４１．６０％。籽粒千粒重和饱满度均超过对照，差异极显著。Ｌ＿１代籽粒出苗率和植株成活率分别比对照提高５８．１８～８３．０６％，４１．３５～８７．７８％，差异均超过极显著水平。Ｌ＿１代种子、植株和穗的大多数形态特征呈中间型或似父本，其余特点象母本。在Ｌ＿１代植株中均获得了染色体自然加倍的双二倍体，即小黑麦种子。现已获得了Ｌ＿１、Ｌ＿２、Ｌ＿３和Ｌ＿４代的小黑麦后代材料。Ｈｅ－Ｎｅ激光诱变小麦属间杂交，使杂种染色体自然加倍，为小麦属间杂交育种工作提供了新的简便途径。     

基于改进遗传算法的多脉冲交会轨道优化研究

最优空间多脉冲轨道交会是一个复杂的非线性系统。由于结构复杂,存在非线性特性,影响系统的快速性和实时性。建立最优空间多脉冲轨道交会模型,传统遗传算法不能满足要求,因此提出了在自适应遗传算法的基础上引入多位变异的多变异位自适应遗传算法,对空间多脉冲交会轨道优化进行了求解。多变异位自适应遗传算法增加了种群的多样性,可避免算法的早熟收敛现象。仿真结果表明,利用多位变异自适应遗传算法求解空间多脉冲交会轨道优化效果好,避免了早期收敛,提高了全局寻优能力,为多脉冲交会轨道优化提供了较好的方法。     

对地观测卫星成像区域仿真研究

为了发挥对地观测卫星在大面积、实时、快速获取地表数据方面的优势,用户需要事先掌握对于自己感兴趣区域上空的卫星过境情况和成像能力。本文通过对卫星轨道预报模型与算法、卫星地面成像区域边界轨迹计算模型和算法的探讨与实践,得到了一些对卫星成像区域仿真有益的经验。试验证明,对于无侧视情况下,使用较旧的卫星轨道根数来计算卫星成像区域,仍能满足用户对于成像区域预报的精度要求。     

等温核酸放大技术在重金属检测方面的应用

等温核酸放大技术是一种可以实现重金属污染物痕量分析的高灵敏性检测方法,在分析检测中有着广泛且重要的作用。本文综述了几种不同的等温核酸放大技术及其在重金属检测方面的应用,阐述分析了各方法的检测原理,为之后建立更加灵敏、快速、准确的检测方法提供了参考。虽然等温核酸放大技术目前主要停留在实验室阶段,并且检测目标有限,但是由于该技术的高灵敏性、特异性以及与其他学科紧密的联系性,具有潜在的应用前景。     

Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity.